Metal-Free Catalytic Nucleophilic Substitution of Propargylic Alcohols

✍ Scribed by Roberto Sanz; Alberto Martínez; Julia M. Álvarez-Gutiérrez; Félix Rodríguez

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 90 KB
• Volume: 2006
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200500960

✦ Synopsis

Abstract

Organic acids such as PTS efficiently catalyze direct nucleophilic substitutions of the hydroxy groups of propargylic alcohols with a large variety of carbon‐ and heteroatom‐centered nucleophiles. Reactions can be conducted under mild conditions and in air without the need for dried solvents. Reactions on multigram scales are also possible. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)