Metal contaminants promote degradation of lipid/DNA complexes during lyophilization
โ Scribed by Marion d.C. Molina; Thomas J. Anchordoquy
- Book ID
- 116274375
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 477 KB
- Volume
- 1768
- Category
- Article
- ISSN
- 0005-2736
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
It is well known that excipients are required to protect nonviral vectors during the lyophilization process. The goal of this study is to describe the stability of lyophilized nonviral vector preparations on pharmaceutically relevant timescales and provide insight into the factors that govern long-t
The incorporation of components with covalently attached polyethylene glycol (PEG) into nonviral vectors has been shown to prevent aggregation in serum and extend the circulating half-life of lipid/DNA complexes (lipoplexes) in vivo. The tendency of synthetic vectors to aggregate during processing a