## Abstract Metal‐catalysed exchange has been used extensively in the laboratories of AstraZeneca plc at R&D Charnwood to label a variety of molecules of pharmaceutical interest with the isotopes of deuterium and tritium. Despite early prejudices against the use of tritiated compounds, particularly
Metal-catalysed hydrogen isotope exchange labelling: a brief overview
✍ Scribed by William J. S. Lockley; J. Richard Heys
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- French
- Weight
- 203 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
An overview is given of this Special Issue of the Journal of Labelled Compounds and Radiopharmaceuticals dealing with the subject of metal‐catalysed hydrogen isotope exchange labelling. In addition to summarizing the areas covered by the contributed papers, the overview also adds some historical information and gives short reviews of those areas and metals, not specifically covered by the contributed papers. Copyright © 2010 John Wiley & Sons, Ltd.
📜 SIMILAR VOLUMES
## Abstract The metal‐catalysed tritium exchange labelling methods available to a contract labelling facility, and the principles that dictate the selection of the most appropriate method are described. Copyright © 2010 John Wiley & Sons, Ltd.
## Abstract Tritium‐labeled Cyclosporin A (**I**) and FK‐506 (**II**) have been prepared using a metal‐catalysed hydrogen isotope exchange procedure and high specific activity tritiated water. Specific activities of the labeled compounds were 0.15 and 0.59 TBq/mmol, respectively. Copyright © 2004 J