✦ LIBER ✦

Metabotropic glutamate receptors: Phosphorylation and receptor signaling

✍ Scribed by Chul Hoon Kim; Jinu Lee; Jae-Youn Lee; Katherine W. Roche

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 191 KB
Volume: 86
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.21437

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of mGluRs affects receptor signaling, trafficking, and desensitization. Here we review the emerging literature on mGluR phosphorylation, signaling, and synaptic function. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Metabotropic glutamate (mGlu) receptors

Metabotropic glutamate (mGlu) receptors and nociceptive processing

✍ T.E. Salt 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB

## Abstract Metabotropic glutamate (mGlu) receptors are found at various levels of the somatosensory/nociceptive signalling pathways from the periphery to the cerebral cortex. The distribution of the receptors in the brain and within and around synapses suggests considerable functional specialisati

Metabotropic glutamate receptors in the

Metabotropic glutamate receptors in the hypothalamus

✍ Maria Angela Sortino; Pier Luigi Canonico 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 610 KB

Ligand Recognition Mechanism of G—CSF Re

Ligand Recognition Mechanism of G—CSF Receptor and Metabotropic Glutamate Receptor

✍ Kosuke Morikawa 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 51 KB

Metabotropic glutamate receptor agonists

Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes

✍ Zu-Cheng Ye; Harald Sontheimer 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB

Astrocytes are thought to control extracellular glutamate concentrations ([Glu] o ) in the brain, thereby protecting neurons from excitotoxic injury. We investigated the effects of metabotropic glutamate receptor (mGluR) agonists on glutamate transport and [Glu] o in primary hippocampal astrocytic c

Developmental changes in metabotropic gl

Developmental changes in metabotropic glutamate receptor-mediated calcium homeostasis

✍ Zirpel, Lance; Janowiak, Mary A.; Taylor, Dwan A.; Parks, Thomas N. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 387 KB

Neurons of the chick cochlear nucleus, nucleus magnocellularis (NM), require eighth nerve activation of metabotropic glutamate receptors (mGluRs) for maintenance of intracellular calcium homeostasis. Interrupting this activation results in an increase in intracellular calcium concentration ([Ca 2ϩ ]

Metabotropic glutamate receptor subtypes

Metabotropic glutamate receptor subtypes independently modulate neuronal intracellular calcium

✍ Kenneth Maiese; Ishtiaq Ahmad; Michelle TenBroeke; Jennifer Gallant 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 291 KB

Metabotropic glutamate receptors (mGluRs) modulate several G-protein-related signal transduction pathways including intracellular calcium (iCa 2؉ ) that control both neuronal development and demise. As an initial investigation, we characterized the ability of specific mGluR subtypes to modulate iCa