✦ LIBER ✦

Metabotropic glutamate (mGlu) receptors and nociceptive processing

✍ Scribed by T.E. Salt

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 111 KB
Volume: 54
Category: Article
ISSN: 0272-4391
DOI: 10.1002/ddr.10012

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✦ Synopsis

Abstract

Metabotropic glutamate (mGlu) receptors are found at various levels of the somatosensory/nociceptive signalling pathways from the periphery to the cerebral cortex. The distribution of the receptors in the brain and within and around synapses suggests considerable functional specialisation and specificity. Functional studies in animals indicate that these receptors can participate in or modulate nociceptive processing. Several classes of mGlu receptor‐active agonists and antagonists have been developed, and some of these appear to be effective in animal models of pain. This indicates that development of subtype‐selective mGlu compounds may be a fruitful avenue for the discovery of analgesic agents with novel mechanisms of action. Drug Dev. Res. 54:129–139, 2002. © 2002 Wiley‐Liss, Inc.

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