Metabotropic glutamate receptors modulate striatal quinolinic acid toxicity
โ Scribed by L.R. Orlando; D.G. Standaert; J.B. Penney Jr.; A.B. Young
- Book ID
- 116037978
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 133 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0028-3908
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## Abstract Metabotropic glutamate receptors (mGluRs) and calcium receptors (CaR) are closely related G proteinโcoupled receptors (GPCRs). The similar structural and functional properties of mGluRs and CaRs include conserved amino acid residues involved in glutamate binding in mGluRs and Ca^2+^ bin
In vivo microdialysis in conscious rats was used to assess the effect of metabotropic glutamate receptor stimulation on striatal dopamine release. Local application of the metabotropic glutamate agonist (ฯฎ)-trans-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD), via a microdialysis probe, produced a