Metabotropic glutamate receptors modulate astrocyte proliferation
β Scribed by R. Ciccarelli; F. Sureda-Battle; L. Dalimonte; V. Bruno; G. Casabona; A. Renzetti; D.F. Condorelli; P. Di Iorio
- Book ID
- 116037924
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 139 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0028-3908
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π SIMILAR VOLUMES
## Abstract Metabotropic glutamate receptors (mGluRs) and calcium receptors (CaR) are closely related G proteinβcoupled receptors (GPCRs). The similar structural and functional properties of mGluRs and CaRs include conserved amino acid residues involved in glutamate binding in mGluRs and Ca^2+^ bin
Astrocytes are thought to control extracellular glutamate concentrations ([Glu] o ) in the brain, thereby protecting neurons from excitotoxic injury. We investigated the effects of metabotropic glutamate receptor (mGluR) agonists on glutamate transport and [Glu] o in primary hippocampal astrocytic c