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Metabotropic glutamate receptor-induced homosynaptic long-term depression and depotentiation in the dentate gyrus of the rat hippocampus in vitro

✍ Scribed by S.M. O'Mara; M.J. Rowan; R. Anwyl

Book ID
116037805
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
626 KB
Volume
34
Category
Article
ISSN
0028-3908

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## Abstract In the hippocampus, synaptic depression of potentiated synapses in the form of depotentiation, or of naive synapses in the form of long‐term depression (LTD) is mediated by distinct molecular mechanisms. Activation of group 1 metabotropic glutamate receptors (mGluRs) is critically requi