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Metabolism of the cholestanol precursor cholesta-4,6-dien-3-one in different tissues

✍ Scribed by Marie S. Buchmann; Ingemar Björkhem; Sverre Skrede

Book ID
115739755
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
592 KB
Volume
922
Category
Article
ISSN
0005-2760

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Accumulation of 7α-hydroxy-4-cholesten-3-one and cholesta-4,6-dien-3-one in patients with cerebrotendinous xanthomatosis: Effect of treatment with chenodeoxycholic acid
✍ Ingemar Björkhem; Sverre Skrede; Marie S. Buchmann; Cara East; Scott Grundy 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 580 KB

Evidence was recently presented that an essential part of the accumulation of cholestanol in patients with cerebrotendinous xanthomatosis is due to acceleration of a novel pathway, involving ?a-hydroxylated intermediates in bile acid biosynthesis as precursors (J. Clin. Invest. 1986; 75:448-456). Su