Metabolism of the A1 adenosine receptor PET ligand [18F]CPFPX by CYP1A2: implications for bolus/infusion PET studies
✍ Scribed by Andreas Matusch; Philipp T. Meyer; Dirk Bier; Marcus H. Holschbach; Dirk Woitalla; David Elmenhorst; Oliver H. Winz; Karl Zilles; Andreas Bauer
- Book ID
- 116799024
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 969 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0969-8051
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## Abstract In an attempt to visualize the NMDA glutamatergic receptors and after checking the biological activity of the cold 3‐fluoromethyl‐TCP 3, 3‐[^18^F]‐fluoro‐methyl‐TCP 4 was synthesized by a nucleophilic substitution of 3‐bromomethyl‐TCP 5 with [^18^F^−^].
## Abstract The feasibility of nucleophilic displacement of bromide in the 4‐bromopyrazole ring with [^18^F]fluoride has been demonstrated by the synthesis of two radiolabeled compounds: __N__‐(piperidin‐1‐yl)‐5‐(4‐methoxyphenyl)‐1‐(2‐chlorophenyl)‐4‐[^18^F]fluoro‐1__H__‐pyrazole‐3‐carboxamide, ([^