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Metabolism of polychlorinated dibenzo-p-dioxins by cytochrome P450 BM-3 and its mutant

✍ Scribed by Woro Triarsi Sulistyaningdyah; Jun Ogawa; Qing-Shan Li; Raku Shinkyo; Toshiyuki Sakaki; Kuniyo Inouye; Rolf D. Schmid; Sakayu Shimizu

Publisher
Springer Netherlands
Year
2004
Tongue
English
Weight
90 KB
Volume
26
Category
Article
ISSN
0141-5492

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Metabolism of polychlorinated dibenzo-p-
Metabolism of polychlorinated dibenzo-p-dioxins by rat liver microsomes
✍ Keke Hu; Nigel J. Bunce πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 121 KB πŸ‘ 1 views

The in vitro metabolism of several chlorinated dibenzo-p-dioxin congeners (PCDDs) was studied using rat liver microsomes as a source of CYP 1 enzymes. The reactions were kinetically first order in both enzyme and substrate and showed a general trend toward decreasing reactivity with increasing chlor