Biotransformation of the Sesquiterpene (+)-Valencene (I) by Cytochrome P450cam and P450BM-3
β Scribed by Rebecca J. Sowden; Samina Yasmin; Nicholas H. Rees; Stephen G. Bell; Luet-Lok Wong
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 9 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Figure 1. Product distributions in the oxidation of alkylbenzenes by wildtype CYP102A1 (WT) and variant KT5 (F87A7A330P/E377A/D425N).
## Abstract Resonance Raman scattering from cytochrome P450 BM3 is obtained with a Raman microprobe using 406βnm excitation with an accumulation time of a few seconds. The small sample size and rapid measurement time make the routine characterization of P450 systems by resonance Raman spectroscopy
## Abstract Herein we demonstrate that a small panel of variants of cytochrome P450 BM3 from __Bacillus megaterium__ covers the breadth of reactivity of human P450s by producing 12 of 13 mammalian metabolites for two marketed drugs, verapamil and astemizole, and one research compound. The most acti