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Metabolism of palmatine by human hepatocytes and recombinant cytochromes P450

✍ Scribed by Vrba, Jiri; Papouskova, Barbora; Pyszkova, Michaela; Zatloukalova, Martina; Lemr, Karel; Ulrichova, Jitka; Vacek, Jan

Book ID
127378949
Publisher
Elsevier Science
Year
2015
Tongue
English
Weight
620 KB
Volume
102
Category
Article
ISSN
0731-7085

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## Abstract Cytochrome P450 (CYP) substrates that yield fluorescent metabolites were used for rapid screening of drug metabolism activities of 13 recombinant human cytochromes P450, human liver microsomes and human hepatocytes. Reproducible results were obtained using a fluorescent plate reader (Cy