✦ LIBER ✦

Metabolism of GABA in retina of diabetic rat

✍ Scribed by Misao Honda; Masanori Ino-ue; Yasuhiro Okada; Misao Yamamoto

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 646 KB
Volume: 24
Category: Article
ISSN: 0893-6609
DOI: 10.1002/(sici)1520-6769(199901/02)24:1<27::aid-nrc4>3.0.co;2-z

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of hyperglycemia on the localization and metabolism of gammaaminobutyric acid (GABA) was examined to elucidate the pathogenesis of deteriorations of electroretinogram oscillatory potentials in streptozotocin-induced diabetic rats.

GABA is localized primarily in amacrine cells in the diabetic retina. GABA content and activities of glutamate decarboxylase (GAD) and GABA transaminase (GABA-T) in the retina and superior colliculus (SC) were determined. GABA content and activities of GAD and GABA-T remained unchanged in retinas and SCs of diabetic rats. Alterations in the GABAnergic system of the retina could not be observed.

GABA metabolism may have no relation with visual dysfunction in diabetes mellitus.

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