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Distribution of sodium valproate and gaba metabolism in cns of the rat

✍ Scribed by Claude Hariton; Lucien Ciesielski; Simone Simler; Marc Valli; Guy Jadot; Serge Gobaille; Edouard Mesdjian; Paul Mandel

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 272 KB
Volume: 5
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510050412

No coin nor oath required. For personal study only.

✦ Synopsis

The distribution of VPA has been investigated in several brain areas of the rat, and GABA increases were measured. A biphasic exponential decay was observed for VPA; the slowest decrease was noted in the olfactory bulbs and in the hypothalamus where GAD and GABA-T activities were the highest. The data may be correlated with the prolonged effect of VPA in these areas.

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