Metabolism of Exogenous Leukotrienes by Cultured Human Keratinocytes.
β Scribed by Morelli, Joseph G.; Norris, David A.; Lyons, M. Bradley; Murphy, Robert C.
- Book ID
- 110689725
- Publisher
- Nature Publishing Group
- Year
- 1990
- Tongue
- English
- Weight
- 839 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0022-202X
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An aromatic retinoid Ro 10-9359 is metabolized after absorption from intestine to form Ro 10-1670 which is an active therapeutic compound. The epidermal keratinocytes, a main target tissue of retinoid therapy in dermatology, was examined in the capacity to metabolize the retinoid. The culture of hum
Cultured human keratinocytes were incubated in the presence of glycolipids (GM1, asialoGM1, glucosylceramide and galactosyiceramide) added to the medium at a concentration of 10-SM. All of them became associated with the cells, but in different amounts depending on the type of glycolipid and on the