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Protective effect of some exogenous glycolipids on human cultured keratinocytes against lipid peroxidation

✍ Scribed by I. Varani; A. Terzaghi; L. Donati; M. Marazzi; M. Masserini; G. Tettamanti

Publisher: Springer-Verlag
Year: 1994
Tongue: English
Weight: 304 KB
Volume: 286
Category: Article
ISSN: 0340-3696
DOI: 10.1007/bf00371576

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✦ Synopsis

Cultured human keratinocytes were incubated in the presence of glycolipids (GM1, asialoGM1, glucosylceramide and galactosyiceramide) added to the medium at a concentration of 10-SM. All of them became associated with the cells, but in different amounts depending on the type of glycolipid and on the time in culture. GM1-and asialoGMl-treated keratinocytes developed a resistance to peroxidative stress induced by FeSO4/H202 treatment. These results suggest that these exogenously added glycolipids could play a role as eutrophic, repairing and protective agents for the epidermis.

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