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Metabolism of Ethyl Carbamate by Pulmonary Cytochrome P450 and Carboxylesterase Isozymes: Involvement of CYP2E1 and Hydrolase A

✍ Scribed by Poh-Gek Forkert; Raymond P. Lee

Book ID
112266494
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
195 KB
Volume
146
Category
Article
ISSN
0041-008X

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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to