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Metabolism of epidoxorubicin in animals: absence of glucuronidation

✍ Scribed by P. A. Maessen; K. B. Mross; H. M. Pinedo; W. J. F. Vijgh

Publisher: Springer
Year: 1987
Tongue: English
Weight: 217 KB
Volume: 20
Category: Article
ISSN: 0344-5704
DOI: 10.1007/bf00252968

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✦ Synopsis

Metabolism of epidoxorubicin was studied in plasma of seven different animal species at 2 h after administration of 4 mg/kg. None of the animals showed significant glucuronidation of epidoxorubicin, although small amounts of the glucuronides could be detected in the rabbit. However, large differences in formation of epidoxorubicinol and 7-deoxy (7d) doxorubicinol aglycone were observed between the species. These phenomena may be relevant for interspecies differences with regard to anthracycline-induced histomorphological changes in for example, heart tissues and cardiotoxicity in relation to formation of 7d aglycones.

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