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Metabolism of cyclic AMP in non-pathogenicMycobacterium smegmatis

✍ Scribed by C. H. Lee

Publisher
Springer
Year
1979
Tongue
English
Weight
257 KB
Volume
120
Category
Article
ISSN
0302-8933

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✦ Synopsis

The intracellular concentration of cyclic AMP reached a maximum in 3.5-day old cultures of Mycobacterium smegmatis grown in the presence of glycerol as the main source of carbon. Glucose-grown cells exhibited decreased cyclic AMP levels at all stages of growth. When M. smegmatis cells were incubated with various metabolites, pyruvate increased whereas glucose, ctric acid, succinic acid and lactic acid decreased intracellular cyclic AMP levels. No cyclic AMP was detected in the incubation medium. The presence of a cyclic AMP-binding protein was demonstrated in cell-free extracts of M. smegmatis.

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