METABOLISM OF BILIRUBIN IN THE GUNN RAT
โ Scribed by Van Leusen, R.; Go, I.H.; Schalm, L.; Okolicsanyi, L.; Magnenat, P.; Frei, J.
- Book ID
- 122871570
- Publisher
- The Lancet
- Year
- 1968
- Tongue
- English
- Weight
- 162 KB
- Volume
- 292
- Category
- Article
- ISSN
- 0140-6736
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๐ SIMILAR VOLUMES
Jaundiced Gunn rats, treated with phenobarbital (60 mg per kg i.p. for 7 to 10 days) showed 25 and 36% decreases in mean plasma bilirubin levels in two experiments (p < 0.01). Kinetic studies with tracer 14C-bilirubin revealed that there was no change in bilirubin turnover or total pool size due to
Tetrachlorodibenzo-p-dioxin, a potent inducer of microsomal cytochrome P448-dependent monoxygenases, and phototherapy both accelerate bilirubin metabolism and decrease jaundice in Gunn rats. The effects of combined treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and light were studied in these ra