Metabolism of benzo[α] pyrene in the combined rat liver —lung perfusion system
✍ Scribed by Michael Mollière; Heidi Foth; Regine Kahl; Georg F. Kahl
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 708 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0300-483X
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Male Wistar rats were continuously exposed to NO 2 (14.4 ppm), SO 2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investig
## Abstract A very large variation (44‐fold) was observed in the ability of short‐term organ cultures of peripheral lung tissue from lung‐cancer patients to metabolize the environmental carcinogen benzo(a)pyrene to organic solvent‐soluble metabolites. The amounts of benzo(a)pyrene (2 μM) metabolize