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Metabolism of 4-Hydroxyaminoquinoline-1-oxide and its binding to DNA in chick embryos

✍ Scribed by Hiroshi Kitani; Mariko Tada; Toshiteru Morita; Yutaka Koshida

Book ID: 113136702
Publisher: Elsevier Science
Year: 1983
Tongue: English
Weight: 576 KB
Volume: 47
Category: Article
ISSN: 0009-2797
DOI: 10.1016/0009-2797(83)90152-7

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## Abstract ## BACKGROUND: During organogenesis the embryo is highly sensitive to oxidative stress. We hypothesize that oxidative stress and activation of a redox‐sensitive transcription factor, activator protein‐1 (AP‐1), are early indicators of embryonic stress in response to a teratogenic insul