Metabolism of [1,3-13C]glycreol-1,2,3-tris(methylsuccinate) and glycerol-1,2,3-tris(methyl[2,3-13C]succinate) in rat hepatocytes
✍ Scribed by Willy J. Malaisse; Laurence Ladrière; Ingrid Verbruggen; Gunnar Grue-Sørenson; Fredrik Björkling; Rudolph Willem
- Book ID
- 117179664
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 702 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1532-8600
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📜 SIMILAR VOLUMES
2-Ethoxy-1-methyl-5-pymlidinone (1) was reacted with ethyl [3,4-'3C2]acetoacetate (2) in the presence of T i c 4 to give ethyl [3,4-13C2]-2-( 1'-methyl-5'oxo-2'-pyrrolidinyl)-3-oxobutanoate (3) in 85% yield. Decarboethoxylation of ethyl [3,4-13C2]-2-( l'-methyl-5'-oxo-2'-pyrrolidiny1)-3-oxobutanoate
Three selectively labeled propynes were prepared either with deuterium or carbon-13 at position 3 and doubly labeled with carbon-13 at positions 1 and 2 by an alkylation reaction from the corresponding labeled or unlabeled monolithio acetylides and dimethylsulfates. Their lithiation with nBuLi gave