Metabolism of 1,25-dihydroxyvitamin D 3 : evidence for side-chain oxidation
✍ Scribed by Kumar, Rajiv; Harnden, Deborah; DeLuca, Hector F.
- Book ID
- 121226220
- Publisher
- American Chemical Society
- Year
- 1976
- Tongue
- English
- Weight
- 464 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0006-2960
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The nuclear hormone 1a,25-dihydroxyvitamin D 3 (1a,25(OH) 2 D 3 ) acts through the transcription factor vitamin D receptor (VDR) via combined contact with the retinoid X receptor (RXR), coactivator proteins, and speci®c DNA binding sites (VDREs). Ligand-mediated conformational changes of the VDR are
AbsWaet: Side chain mobility of 1,25(OH)2D3 (1) and its 20-epimer (2) was analyzed and shown in a threedimensional dot map that indicates the two distinct spatial regions accessible by the terminal 25-hydroxyl group for each vitamin. The biological activities of two analogs (3 and 4) of 1, which pos