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Metabolism of [123I]epidepride may affect brain dopamine D2receptor imaging with single-photon emission tomography

✍ Scribed by Kim A. Bergström; Meixiang Yu; Jyrki T. Kuikka; Kari K. Åkerman; Jukka Hiltunen; Johannes Lehtonen; Christer Halldin; Jari Tiihonen

Publisher: Springer
Year: 2000
Tongue: English
Weight: 67 KB
Volume: 27
Category: Article
ISSN: 0340-6997
DOI: 10.1007/s002590050028

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## Abstract Iodobenzamide (IMB) labeled with either [^11^C] or [^125^I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D~2~ dopamine receptors. Mouse biodistribution studies with both [^11^C]IMB and [^125^I]IMB showed a similar brain