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Metabolism and effects on cholestasis of isoursodeoxycholic and ursodeoxycholic acids in bile duct ligated rats

✍ Scribed by Edmund Purucker; Hanns-Ulrich Marschall; Ron Winograd; Siegfried Matern

Book ID
117480767
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
478 KB
Volume
1526
Category
Article
ISSN
0304-4165

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Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Despite limited benefits, ursodeoxycholic acid (UDCA) is the only Food and Drug Administration-approved treatment for cholestatic disorders. Retinoic acid (RA) is a ligand for nuclear receptors that modulate bi