Combination of retinoic acid and ursodeo
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Hongwei He; Albert Mennone; James L. Boyer; Shi-Ying Cai
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Article
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2010
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John Wiley and Sons
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English
β 493 KB
Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Despite limited benefits, ursodeoxycholic acid (UDCA) is the only Food and Drug Administration-approved treatment for cholestatic disorders. Retinoic acid (RA) is a ligand for nuclear receptors that modulate bi