## Abstract Metabolism of the carcinogenic hydrocarbon benzo(a)pyrene (BP) to water and alkaliโsoluble products was measured in cultured fibroblast and epithelial cells from human embryos. The alkaliโsoluble products represented only a small fraction of BP metabolism. Fibroblasts from different org
Metabolism and binding of benzo[a]pyrene in randomly-proliferating, confluent and s-phase human skin fibroblasts
โ Scribed by Mary Jane Cunningham; Ponnamma Kurian; George E. Milo
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 886 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0742-2091
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โฆ Synopsis
role in the expression of a transformed phenotype and that metabolism and transformation are not directly related. Furthermore, confluent dense cultures with a heightened capability for metabolism of benzo[a~yrene were more active in the detoxification of benzo[a~oyrene than in the production of the metabolites associated with cellular transformation.
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## Abstract DNA has been isolated from human bronchial segments that have been treated in shortโterm organ culture with ^3^Hโlabelled benzo(a)pyrene. DNA has also been isolated from mouse skin treated with ^3^Hโlabelled samples of benzo(a)pyrene, with the related radioactive 4,5โ, 7,8โ and 9,10โdih
## Abstract Aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity and metabolism of benzo(a)pyrene to waterโsoluble products were measured in cultures of body fibroblasts and kidney epithelial cells from different human embryos. AHH activity at 24 h after treatment with or without benz(a)ant