Metabolic studies of 5-fluorouracil—II. Influences of the route of administration on the dynamics of distribution in man

✍ Scribed by H. O. Douglass Jr.; A. Mittelman

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 312 KB
• Volume: 34
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197412)34:6<1878::aid-cncr2820340604>3.0.co;2-c

✦ Synopsis

Portal and peripheral plasma and bile levels of 5-fluorouracil were determined after oral and intravenous administration of the 2-14C labelled isotope in man.

Initial peak levels of radioactivity resulting from intravenous administration were followed by a rapid disappearance of the isotope. Ingested drug appeared in the portal plasma in less than 5 minutes and resulted in sustained higher concentrations in the plasma and bile 30 to 60 minutes later. Significant 5-fluorouracil is excreted into the gut via the biliary tree. Sustained portal concentrations of active drug suggest that continued absorption from the small intestine occurs.