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Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview

✍ Scribed by Chantal Guillemette, Alain Bélanger, Johanie Lépine


Book ID
120700447
Publisher
BioMed Central
Year
2004
Tongue
English
Weight
596 KB
Volume
6
Category
Article
ISSN
1465-5411

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L Y I 17018 is a non-steroid anti-estrogen which exhibits about 100 times higher affinity for estrogen receptor than tamoxifen, another anti-estrogen. The cell line ES-I , which was isolated from human breast cancer MCF-7 cells, was highly sensitive to the cytocidal action of estradiol. Growth of ES