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Zafirlukast Metabolism by Cytochrome P450 3A4 Produces an Electrophilic α,β-Unsaturated Iminium Species That Results in the Selective Mechanism-Based Inactivation of the Enzyme

✍ Scribed by Kassahun, Kelem; Skordos, Konstantine; McIntosh, Ian; Slaughter, Donald; Doss, George A.; Baillie, Thomas A.; Yost, Garold S.


Book ID
120592218
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
247 KB
Volume
18
Category
Article
ISSN
0893-228X

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