Metabolic disease: Dual benefit of bile acid receptor agonist
โ Scribed by Crunkhorn, Sarah
- Book ID
- 109950967
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 218 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1474-1776
- DOI
- 10.1038/nrd3032
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Abbreviations ## CDCA chenodeoxycholic acid Cyp7A cholesterol 7ฮฑ-hydroxylase DCA deoxycholic acid FRET fluorescence resonance energy transfer FXR farnesoid X receptor LCA lithocholic acid LRH-1 liver receptor homologue-1 LXR liver X receptor RXR retinoid X receptor SF-1 steroidogenic factor-1
## Abstract Chemical genomics is the name we have given to the analysis of gene function through use of small molecule chemical tools. Orphan nuclear receptors are ideally suited to this technique of functional analysis, since their activity as transcription factors is regulated by small hydrophobi