Metabolic conversion and growth effects of n-6 and n-3 polyunsaturated fatty acids in the T47D breast cancer cell line
β Scribed by Sylvie Bardon; Mai Thanh Le; Jean-Marc Alessandri
- Book ID
- 116123363
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 571 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0304-3835
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The metabolic conversion of n-3 fatty acids was studied in the human Y79 retinoblastoma cell line. Cultured cells were exposed to increasing concentrations of either 18:3n-3, 22:5n-3, or 22:6n-3, and their phospholipid fatty acid composition was analyzed after 72 hr. Cells internalized the supplemen
Dietary n-3 polyunsaturated fatty acids (PUFAs) have been found to reduce accelerated cell growth. To study the underlying molecular mechanisms, we evaluated the effects of the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) compared with the n-6 PUFA arachidonic acid (AA) on ce