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Metabolic control of energy flux

โœ Scribed by Howard E. Morgan


Book ID
119441737
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
78 KB
Volume
18
Category
Article
ISSN
0022-2828

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๐Ÿ“œ SIMILAR VOLUMES


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Metabolic Control Analysis has invalidated many traditional biochemical concepts of control, in particular the rate-limiting step. However, it has not been used to question the mechanisms by which pathway flux is thought to be controlled, such as the action of allosteric effectors or of covalent mod

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The problems of engineering increased flux in metabolic pathways are analyzed in terms of the understanding provided by metabolic control analysis. Overexpression of a single enzyme is unlikely to be effective unless it is known to have a high flux control coefficient, which can be used as an approx