✦ LIBER ✦

Distribution control of metabolic flux

✍ Scribed by Richard L. Veech; David A. Fell

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 713 KB
Volume: 14
Category: Article
ISSN: 0263-6484
DOI: 10.1002/cbf.697

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Design of Metabolic Control for Large Fl

Design of Metabolic Control for Large Flux Changes

✍ Simon Thomas; David A. Fell 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 260 KB

Metabolic Control Analysis has invalidated many traditional biochemical concepts of control, in particular the rate-limiting step. However, it has not been used to question the mechanisms by which pathway flux is thought to be controlled, such as the action of allosteric effectors or of covalent mod

Bacterial Adaptation through Distributed

Bacterial Adaptation through Distributed Sensing of Metabolic Fluxes

✍ M. Heinemann; O. Kotte; J. B. Zaugg 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 German ⚖ 46 KB

Increasing the flux in metabolic pathway

Increasing the flux in metabolic pathways: A metabolic control analysis perspective

✍ David A. Fell 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 32 KB 👁 1 views

The problems of engineering increased flux in metabolic pathways are analyzed in terms of the understanding provided by metabolic control analysis. Overexpression of a single enzyme is unlikely to be effective unless it is known to have a high flux control coefficient, which can be used as an approx

Experimental determination of group flux

Experimental determination of group flux control coefficients in metabolic networks

✍ Troy W. Simpson; Hiroshi Shimizu; Gregory Stephanopoulos 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 84 KB

Grouping of reactions around key metabolite branch points can facilitate the study of metabolic control of complex metabolic networks. This top-down Metabolic Control Analysis is exemplified through the introduction of group (flux, as well as concentration) control coefficients whose magnitudes prov

Metabolic Flux Analysis in Synechocystis

Metabolic Flux Analysis in Synechocystis Using Isotope Distribution from 13C-Labeled Glucose

✍ Chen Yang; Qiang Hua; Kazuyuki Shimizu 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 433 KB

Using the carbon isotope labeling technique, the response of cyanobacterial central carbon metabolism to the change in environmental conditions was investigated. Synechocystis was grown in the heterotrophic and mixotrophic cultures fed with 13C-labeled glucose. The labeling patterns of the amino aci

Heterogeneous distribution and organizat

Heterogeneous distribution and organization of cytoskeletal proteins drive differential modulation of metabolic fluxes

✍ M.A. Aon; A. Cáceres; S. Cortassa 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 696 KB

On the basis of experimental data obtained in vitro, we propose that differential segregation of actin and tubulin in the cytoplasm may be a regulatory mechanism of metabolic fluxes. The results presented point out that the same enzymes may be differentially modulated at different locations in the c