Ethosuximide is a chiral drug substance primarily indicated for the treatment of absence seizures. This drug is used clinically as the racemate. The urinary metabolites of ethosuximide (following i.p. administration of the racemate or individual enantiomers to rats) have been studied using chiral ga
Metabolic aspects of the rhythmogenesis inAplysiapacemaker neurons
β Scribed by C. F. Chen; R. Baumgarten; O. Harth
- Publisher
- Springer
- Year
- 1973
- Tongue
- English
- Weight
- 839 KB
- Volume
- 345
- Category
- Article
- ISSN
- 0031-6768
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Nicotine-iminium ions -Trans-3"-hydroxycotinine -5'-hydroxycotinine It has long been generally accepted that the most important pathway in the oxidative degradation of nicotine in humans is oxidation at the ~C atom in the 5' position of the pyrrolidine ring of nicotine. This attack is the origin of
## Abstract Ethosuximide is a chiral drug substance primarily indicated for the treatment of absence seizures. This drug is used clinically as the racemate. The human urinary metabolites of ethosuximide (I) have been studied using chiral gas chromatography (GC) and gas chromatography/mass spectrome