Metabolic and secretory response of tumoral-insulin producing cells to D-fructose and D-galactose

✍ Scribed by Marie-Hélène Giroix; François Blachier; Abdullah Sener; Willy J. Malaisse

• Book ID: 104671420
• Publisher: Springer
• Year: 1987
• Tongue: English
• Weight: 565 KB
• Volume: 74
• Category: Article
• ISSN: 0300-8177
• DOI: 10.1007/bf00224954

✦ Synopsis

At variance with normal islet cells, tumoral insulin-producing cells of the RINm5F line were found to display a positive secretory response not solely to D-glucose and D-mannose, but also to D-fructose and D-galactose. All hexoses increased the ATP/ADP ratio, exerted a sparing action upon the oxidation of endogenous nutrients in cells prelabelled with either L-[U-14C]glutamine or [U-14C]palmitate, increased the output of lactic acid and, as judged from data collected in the presence of D-[U-14C]hexoses, underwent oxidation in the RINm5F cells. The secretory response to these four hexoses appeared commensurate with the extent of their metabolic effects.