Metabolic activation of diethylstilbestrol and aminostilbene-derivatives

✍ Scribed by H. -G. Neumann; M. Metzler; W. Töpner

• Book ID: 104731574
• Publisher: Springer-Verlag
• Year: 1977
• Tongue: English
• Weight: 555 KB
• Volume: 39-39
• Category: Article
• ISSN: 0340-5761
• DOI: 10.1007/bf00343272

✦ Synopsis

Diethylstilbestrol and trans-4-dimethylaminostilbene are metabolically activated and several of their metabolites are able to react with cellular macromolecules. Some of the problems are discussed which are encountered in linking a particular metabolite with the mutagenic and carcinogenic properties of these compounds.