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Meta-analysis by random effect modelling in generalized linear models

✍ Scribed by Murray Aitkin

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
94 KB
Volume
18
Category
Article
ISSN
0277-6715

No coin nor oath required. For personal study only.

✦ Synopsis

The meta-analysis of multi-centre trials can be based on either "xed or random e!ect models. This paper argues for the general use of random e!ect models, and illustrates the value of non-parametric maximum likelihood (NPML) analysis of such trials. The same general approach uni"es administrative &league table' analyses in epidemiological and other studies. Several examples of the NPML analysis are given, including a 70-centre trial.

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