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Mesoionic purinone analogs as inhibitors of cyclic-AMP phosphodiesterase: comparison of several ring systems

โœ Scribed by Rogers, Michael E.; Glennon, Richard A.; Smith, J. Doyle; Boots, Marvin R.; Nanavati, Nitin; Maconaughey, Julie E.; Aub, Debbie; Thomas, Sheree; Bass, R. G.; Mbagwu, Godwin


Book ID
124051273
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
496 KB
Volume
24
Category
Article
ISSN
0022-2623

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๐Ÿ“œ SIMILAR VOLUMES


Mesoionic xanthine analogs as inhibitors
โœ R. A. Glennon; M. E. Rogers; R. G. Bass; S. B. Ryan ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 383 KB

Several derivatives of two mesoionic xanthine analogs, mesoionic thiazolo[3,2-alpha]pyrimidine-5,7-diones and mesoionic 1,3,4-thiadiazolo[3,2-alpha]pyrimidine-5,7-diones, were synthesized and evaluated as inhibitors of cyclic AMP phosphodiesterase. A significant number of these compounds demonstrate