Mesoionic xanthine analogs as inhibitors
โ
R. A. Glennon; M. E. Rogers; R. G. Bass; S. B. Ryan
๐
Article
๐
1978
๐
John Wiley and Sons
๐
English
โ 383 KB
Several derivatives of two mesoionic xanthine analogs, mesoionic thiazolo[3,2-alpha]pyrimidine-5,7-diones and mesoionic 1,3,4-thiadiazolo[3,2-alpha]pyrimidine-5,7-diones, were synthesized and evaluated as inhibitors of cyclic AMP phosphodiesterase. A significant number of these compounds demonstrate