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Merrilactone A, a novel neurotrophic sesquiterpene dilactone from Illicium merrillianum

✍ Scribed by Jian-mei Huang; Ritsuko Yokoyama; Chun-shu Yang; Yoshiyasu Fukuyama

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 176 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01023-6

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✦ Synopsis

Merrilactone A, isolated from the pericarps of Illicium merrillianum, shows an intriguing neurotrophic activity in the cultures of fetal rat cortical neurons. Its structure has been elucidated to be a unique sesquiterpene bearing two g-lactones and an oxetane ring by extensive analyses of spectral data and then con®rmed by X-ray crystallographic analysis. Further, the absolute con®guration has been established by the modi®ed Mosher's method.

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