✦ LIBER ✦

Merging bottom-up and top-down approaches to study prostate cancer biology

✍ Scribed by The Prostate Cancer Complexity Working Group

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 295 KB
Volume: 7
Category: Article
ISSN: 1076-2787
DOI: 10.1002/cplx.10036

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The sequencing of the human genome has opened new areas of possibility for understanding diseases such as cancers. Sequencing has given us the necessary building blocks for identifying the components of important signaling networks, whereas new tools such as automated gene sequencing, cDNA microassays, and tissue arrays are beginning to produce a torrent of data about these components. As we determine the components of these signaling networks, we can learn how the components are altered by transformations in the cell DNA. However, this torrent of information has also imposed a barrier: It is often unclear how to organize and use the data in ways that tell us more about the signaling networks. As with building blocks in a box, many of the components are still to be assembled into coherent structures. © 2002 Wiley Periodicals, Inc.

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