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Mercury in organic chemistry X. A novel synthesis of Δ∝,β-butenolides

✍ Scribed by Richard C. Larock; Bernhard Riefling

Publisher
Elsevier Science
Year
1976
Tongue
French
Weight
219 KB
Volume
17
Category
Article
ISSN
0040-4039

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✦ Synopsis

Unsaturated five member ring lactones, butenolides, occur widely in natures and possess an unusual range of biological activity.4 They appear throughout the plant and animal kingdoms and hold promise as insecticides, herbicides and plant growth regulators. Of considerable importance is their widespread allergenic, antibacterial and antifungal activity. An increasing number of butenolides exhibit cytotoxic and/or tumor inhibitory properties towards a variety of cancers. This unusual range of biological activity has stimulated considerable research on the synthesis of these valuable compounds.' Our research into possible synthetic applications of vinylmercurials recently provided a convenient new route from acetylenes to a,B-unsaturated carboxylic acids and esters by the palladium promoted carbonylation of vinylmercurials." During that work we observed that B-chloro-g":JB-butenolide can

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