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Mercury elevates systolic blood pressure in spontaneously hypertensive rats

✍ Scribed by Hiroki Takahashi; Hiroko Nomiyama; Kazuo Nomiyama

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
166 KB
Volume
13
Category
Article
ISSN
0896-548X

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✦ Synopsis

Five groups of 18 male spontaneously hypertensive rats (total: 90) were fed pelleted food containing mercuric chloride (HgCl 2 ) at mercury dose levels of 0, 1, 3, 10, and 30 g/g over a period of 12 weeks. An age-related increase in blood pressure was observed in all groups receiving mercury. Our data also suggested that blood pressure was elevated through mercury-induced atherosclerosis in hypertensive rats, but the mechanism was not fully elucidated.

πŸ“œ SIMILAR VOLUMES

Mercury exposure does not elevate systol
Mercury exposure does not elevate systolic blood pressure in normotensive rats
✍ Hiroki Takahashi; Hiroko Nomiyama; Kazuo Nomiyama πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 122 KB

Wistar-Kyoto rats are the original normotensive strain of the spontaneously hypertensive rat (SHR). Fifty male Wistar-Kyoto rats were fed 15 g/day of pelleted food containing mercuric chloride (HgCl 2 ) at dose levels of 0, 1, 3, 10, or 30 g/g over a period of 21 weeks. No dose-related difference in