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Mercapturic acid formation in the metabolism of propachlor, CDAA, and fluorodifen in the rat

✍ Scribed by Gerald L. Lamoureux; Kenneth L. Davison


Book ID
119026699
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
860 KB
Volume
5
Category
Article
ISSN
0048-3575

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Hexachloro-1,3-butadiene (HCBD) is more nephrotoxic to female than male rats. Metabolism of HCBD involves conjugation with glutathione followed by formation of the cysteine conjugate S-(pentachloro-1,3-butadienyl) cysteine (PCBD-CYS) and then the mercapturic acid N-acetyl-S-pentachloro-1,3-butadieny