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Menaquinone (vitamin K2) biosynthesis in Escherichia coli: synthesis of o-succinylbenzoate does not require the decarboxylase activity of the ketoglutarate dehydrogenase complex

โœ Scribed by Marley, M. G.; Meganathan, R.; Bentley, Ronald


Book ID
126979020
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
532 KB
Volume
25
Category
Article
ISSN
0006-2960

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Vitamin K (menaquinone) biosynthesis in
โœ Janet L. Popp; Christine Berliner; Ronald Bentley ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 640 KB

An early enzyme in menaquinone (vitamin K2) biosynthesis is the synthase forming 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) from isochorismic acid. In turn, SHCHC is aromatized to o-succinylbenzoic acid (OSB) by OSB synthase. An assay for the combined activity of these two enz