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Formation of o-Succinylbenzoic Acid from α-Ketoglutaric and Iso-chorismic Acid: The Key Reaction in Menaquinone (Vitamin K2) and Anthraquinone Biosynthesis

✍ Scribed by A. WEISCHE; M. SIMANTIRAS; E. LEISTNER

Book ID
119862691
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
87 KB
Volume
573
Category
Article
ISSN
0890-6564

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Vitamin K (menaquinone) biosynthesis in bacteria: High-performance liquid chromatographic assay of the overall synthesis of o-succinylbenzoic acid and of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase
✍ Janet L. Popp; Christine Berliner; Ronald Bentley 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 640 KB

An early enzyme in menaquinone (vitamin K2) biosynthesis is the synthase forming 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) from isochorismic acid. In turn, SHCHC is aromatized to o-succinylbenzoic acid (OSB) by OSB synthase. An assay for the combined activity of these two enz