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Membrane lipid modifications: Biosynthesis and identification of phosphatidyl-N-methyl-N-isopropylethanolamine in rat liver microsomes

✍ Scribed by Claudia Moore; Merle L. Blank; Ten-Ching Lee; B. Benjamin; Claude Piantadosi; Fred Snyder

Publisher: Elsevier Science
Year: 1978
Tongue: English
Weight: 661 KB
Volume: 21
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(78)90064-6

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✦ Synopsis

In previous studies on the modification of polar he~.d groups of membrane p~ ospheiipids with the upnaParal base analog, N-isopropylethanolamine, we reported an unide~tff~d p~ospholipid in addition to phosphatidyl-N-isopropyle~anotamine in the vario~ m~mbran~ tYactions of rat liver. The structure of this phospholipkl has now been ~enfified as pho~fl~tidyl-N o methyl-N-isopropylethanolawm~e by nuclear magnetic resonance spectroscJ~ y, and t~y chromatographic and e~zymic analysis. In addition, we found that when ~at; were injected intraperitoneally with the N-methyl-N-isopropytezhanotamine, 19% of :b~: 1i ,'or microsomal phospholipid was phosphafidyl-lC-methyl-N-isopropylethanotam~,e.

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