Rilmazafone (RZ) is an orally active sleep inducer which can be activated to its cyclic form (Ml) via the labile desglycylated metabolite (DG). In this scheme, RZ is exclusively metabolized to DG and M1 by aminopeptidases in the small intestine. The concentration of M1 in the systemic plasma after o
Membrane-limited hepatic transport of the conjugative metabolites of 4-methylumbelliferone in rats
โ Scribed by Seiji Miyauchi; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 666 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The Dubin-Johnson syndrome is manifested by conjugated hyperbilirubinemia and pigment accumulation in hepatocellular lysosomes. The TR-rat model is a phenotypic model of the Dubin-Johnson syndrome and is characterized by defective ATP-dependent transport of a group of nonbile acid organic anions, in
The effect of secretin (0.4 C.U. per hr per 100 gm body weight) on bile flow and the apparent maximal hepatic transport of bilirubin (Tm) was investigated in the rat. When secretin was administered during an already established bilirubin-Tm condition, it increased bile flow and bilirubin-Tm by 15 to
Bacterial transport systems are traditionally treated as enzymes exhibiting a saturable binding site giving rise to an apparent K K of transport, whereas the maximal rate of transport is regarded equivalent to the < K?V of enzymatic reactions. Thus, the Michaelis}Menten theory is usually applied in